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48 Overall, it is suggested that glutathione might promote pheomelanin synthesis, inhibit intracellular melanogenic enzymes, and exhibit antioxidant and anti-aging effects

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Furthermore, the amide group can also be transferred to formylglycinamide ribonucleotide (FGAR), which in turn forms formylglycinamidine ribonucleotide (FGAM) for nucleotide synthesis by phosphoribosylformylglycinamidine synthase (PFAS)

When glutathione is depleted, these detoxification pathways become impaired, leading to toxic buildup that can worsen liver damage