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Transdermal Semaglutide Administration in Mice: Reduces Body Weight by Suppressing [PMID: 40427764] Laboratory literature summary: Transdermal Semaglutide Administration in Mice: Reduces Body Weight by Suppressing feeding-behavior endpoints and Enhancing Metabolic Rate

And I just wasnt seeing enough of a change

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Dose Recommendations: Usually initiated at 12 sprays (approximately 0.52 mg per spray) per nostril, titrated based on patient response and tolerability

In brain, sirolimus enhances the distribution of CsA into mitochondria, accentuating its effects of decreasing mitochondrial metabolism, whereas everolimus appears to antagonize the effects of CsA in mitochondria to increase energy metabolism (67, 98)

Of course, it's a good school