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The D-alanine substitution at position 2 specifically targets the primary DPP-4 cleavage site that limits Sermorelins in vivo stability, and additional substitutions further extend resistance to enzymatic degradation in biological matrices

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[53] Substitutions are made at GLP positions 8 and 34 (semaglutide positions 2 and 28), where alanine and lysine are replaced by 2-aminoisobutyric acid and arginine, respectively

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[3] Pharmacology [edit] Afamelanotide is a synthetic tridecapeptide and a structural analogue of -melanocyte stimulating hormone (-MSH)