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Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum

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The myotendinous junction, where muscle transitions to tendon, represents another injury-prone area addressed in research

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Once the mPTP opens, the mitochondrial membrane potential is compromised, respiratory chain function is impaired, ATP synthesis is reduced, and cellular energy metabolism is disrupted