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The pathway is initiated by the deamination of phenylalanine-by-phenylalanine ammonia-lyase (PAL), followed by sequential hydroxylation and activation by cinnamate-4-hydroxylase (C4H) and 4-coumarate-CoA ligase (4CL) to generate p-coumaroyl-CoA ( Figure 1 )

doi:10.1016/j.pharmthera.2010.01.003

Early signs of aging include skin sagging and loss of elasticity

Am J Reprod Immunol

Active cancer, pregnancy, and uncontrolled diabetes change the answer

Its functions in the body are suggested to be complementary to those of caffeine, acting as a phosphodiesterase inhibitor and central nervous system stimulant [28]