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Interestingly, Fab 3F52 also blocked a short peptide agonist believed to engage primarily the transmembrane and extracellular loop region of GLP-1R, whereas functionality of an allosteric small-molecule agonist was not inhibited

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The peptide interacts with the nitric oxide system, which regulates blood flow, inflammation, and cellular signaling

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Indeed it consists of two transmembrane domains, a large extracellular domain, and two short intracellular domains that are required for CD36 function after substrate binding (Su and Abumrad, 2009)

August 2022