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It can be used for combating heart disease, liver disease, alcohol use disorder, and even aging

277,278 Complementing these cellintrinsic models, Farrell extended network adaptation to the tumor microenvironment, arguing that resistance is ecologically driven by crosstalk among cancer cells, CAFs, and macrophages via paracrine signals and exosomes, enabling noncellautonomous drug tolerance

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Conversely, a metabolic labeling experiment validated that P.g could translocate to the gastrointestinal tract in a viable state and elicit insulin resistance, while administration of pasteurized P.g had no such effect (Niu et al., 2024)

These results support a model in which procaspase-1-cleaving X(PC) activates multiple cell death pathways, including both apoptotic and lytic programs, whereas gasdermin D-cleaving X(GD) acts through a more selective lytic mechanism