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Moderate pain lasting more than 3 weeks, or severe pain that limits function, warrants immediate communication with your care providerthese may signal that your dose pace is too aggressive for your individual physiology

Jia Q, Yang R, Liu X-F, Ma S-F

Those who are pregnant, breastfeeding, or trying to conceive

Melatonin receptor signaling: impact of receptor oligomerization on receptor function

Your PlexusDx provider reviews your complete medication list during your initial consultation to identify any risky drug combinations before you begin treatment

10.1038/ncomms11934 140 IulianoE.di CagnoA.AquinoG.FiorilliG.MignognaP.CalcagnoG.et al (2015)