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REDEFINE 2 -- CagriSema in T2D (Lingvay et al., 2025): Significant weight loss and glycemic improvement in adults with overweight/obesity and type 2 diabetes

In addition, HFD also promotes apoptotic processes at the hypothalamic level 62 , and weight-lowering therapies, as exercise, contribute to mitigate apoptosis in hypothalamic neurons 60