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Accumulated ROS under pathological conditions-such as inflammation, ischemia, or denervation-activate upstream kinases (ASK1, MKK3/6, MKK4/7), leading to p38 and JNK phosphorylation
J., Brach, T., Marty, L., Kreye, S., Rouhier, N., Jacquot, J
37,38 This discovery is regarded as a milestone in metabolic research and provides crucial insights into the mechanisms underlying energy production in cells under aerobic conditions
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