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Moreover, clinical trials using traffic violations or accidents as outcomes face major ethical and methodological barriers, including safety concerns and large sample size requirements
However, it also presents new challenges
Adherence remains an important challenge, but it may not be sufficient for critical disease activity or advanced fibrosis (101)
They can cause GI side effects (nausea, reflux, constipation), and in some cases may be associated with gallbladder issues or other risks
Wegovy and Ozempic offer standard dosages and are widely recognized
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