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Direct and Indirect Effects of GLP-1 and GIP Receptor Agonism in the Human Body 2,4,5,12 In addition to their beneficial actions in diabetes and obesity, new research suggests that incretin-based therapies may reduce inflammation in the heart, liver, kidneys, and brain

Other Cardiovascular Benefits of Saxenda Beyond potential effects on cholesterol, Saxenda may confer broader cardiovascular benefits through multiple mechanisms related to weight loss and metabolic improvement

Furthermore, adipose tissue (body fat) is biologically active and secretes pro-inflammatory cytokines

This can cause mild stomach discomfort and occasionally allergic reactions

No published protocols

In this review, we present the efficacy and safety data for the pipeline of obesity pharmacotherapies with a focus on entero-pancreatic hormone-based treatments and we consider the clinical implications and challenges that the new era in obesity management may bring