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Over 89% of participants at this dose level lost at least 5% of their body weight, and a substantial proportion lost 20% or more

At the conclusion of the STEP 1 trial, the average weight loss among the 1,961 participants averaged 14.9% of their initial body weight.[2] For example, if a participant started at 260 pounds and lost 14.9% of their body weight, they would have lost 38.7 pounds

Diuretics may increase the risk of dehydration, especially in patients with persistent vomiting and diarrhea

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Studies on GLP-1 medications have found that they can all lead to weight loss (about 4.8 to 7.2kg (10.5 to 15.8 pounds) when using liraglutide and 15.3kg (33.7 pounds) when using semaglutide and making lifestyle changes

This strengthens sensations of fullness and satisfaction from food