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Physician-formulated for GLP-1 users
Its a clinician-guided approach that emerged as providers noticed that some patients experienced meaningful benefits without needing higher doses
Their earlier structural optimization efforts led to the identification of Compound 76 , a potent PDE10A inhibitor, with poor physicochemical properties and off-target activities
The RNA-seq and qRT-PCR results for both up- and downregulated genes showed a strong positive association (r = 0.854, p = 0.007
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