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These gastrointestinal effects usually diminish over time but can be troublesome for some patients
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In the STEP and SURMOUNT trial programs, participants treated with semaglutide and tirzepatide respectively achieved average weight reductions of 15 to 22% of total body weight, losses that had previously been achievable only through bariatric surgery [8,9]
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4 A 2026 cohort study using U.S
Of the 100 patients initially enrolled in the study, 11 were classified as dropouts due to being lost to follow-up, while 4 patients discontinued treatmentone due to hypoglycemia, one due to lack of efficacy, and two due to challenges in accessing the medicationresulting in 85 patients completing therapy until the studys conclusion
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