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For gel source data, see Supplementary Fig
Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic
Effect of industrial and domestic ash from biomass combustion, and spent coffee grounds, on soil fertility and plant growth: Experiments at field conditions
Naunyn-Schmiedebergs Arch Pharmacol 110
These may include headaches, nausea, injection site reactions since its administered via a subcutaneous injection, water retention, and altered cortisol levels
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