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Serious events (like severe pancreatitis or major liver issues) have been rare and similar to placebo so far, but long-term safety is still being monitored in ongoing phase 3 programmes

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However, despite improvements in OSA-related symptoms and hypertension, PAP has not demonstrated a benefit on composite cardiovascular endpoints in randomized controlled trials for primary [23] or secondary cardiovascular prevention [24,25,26]

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72 To compensate for reduced energy production, dysfunction mitochondria may increase in number and activity