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A shift in focus from end-stage pathology to early intervention and neuronal preservation will be essential to transform the management of AD and improve outcomes for millions of affected individuals

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Extravasation leads to a regional signal change on the MRI image, due to the magnetic properties of GBCAs, which cause shortening of T1 relaxation times (Box 1)

By targeting NNMT and supporting NAD+ levels, it addresses cellular energy metabolism rather than manipulating appetite or stimulating the nervous system

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