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The brain-access hypothesis and why it is contested One influential hypothesis for making sense of these mixed results, advanced by Christian Holscher, proposes that neuroprotective efficacy tracks a compounds ability to reach the brain

doi:10.1016/S0002-9440(10)61673-2

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Melatonin ameliorates age-related sarcopenia via the gut-muscle axis mediated by serum lipopolysaccharide and metabolites