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These mice exhibited reduced trabecular bone mass due to increased osteoclast activity, suggesting lower biomechanical strength [41]

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In the long term, weight change itself is meaningful: clinical trials, the Weight Loss Study, found that semaglutide can reduce body weight by an average of 10% over 68 weeks, which helps explain why lipid and glucose levels often change

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up to 20-30% of older adults struggle with it due to lower stomach acid

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