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Youre upregulating growth factors, promoting angiogenesis, and accelerating healing processes
Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)
Moderation is key to preserving these levels
[56] Serum haptocorrin binds 80-90% of circulating B 12 , rendering it unavailable for cellular delivery by transcobalamin II
Stopping criteria: Height velocity below 4 cm/year at any mid-pubertal assessment
In the REDEFINE trials both components step up together about once a month so the gut adapts
