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This analysis further assessed whether the increase in DRP was a GLP-1 specific effect, or rather caused by a robust and early glucose lowering as suggested by several other studies, where acute and large reductions in glucose concentrations may initially and transiently worsen DRP, yet prevent or delay onset or progression of DRP in the long term (123128)

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When combined with GLP-1 agonism, glucagon receptor activation increases energy expenditure through thermogenesis, enhances fat oxidation and breakdown, improves metabolic rate in ways that counteract the metabolic slowdown typically accompanying weight loss, and may provide additional central appetite regulation

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It is unknown if it causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans

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