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Gen Comp Endocrinol (2018) 260:517

All told, Mounjaro and other medications in the GLP-1 family are thought to help lower your set point: the weight your body naturally settles at due to an interplay of genetics, biology, and environment

[8] One such potential pathway involves the activation of phospholipase C (PLC), which researchers suggest may lead to the release of inositol triphosphate (IP3) and diacylglycerol (DAG)

These effects generally indicate either starting doses too high or individual sensitivity

Higher doses of any medication are more likely to cause side effects because there is more of the drug in your body, which can lead to a stronger reaction