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This results in ER stress, protein misfolding, protein accumulation, mitochondrial dysfunction, inflammation, and apoptosis, all of which severely impair spermatogenesis [24, 160]
The assay demonstrates high sensitivity, as evidenced by its low detection limits (LOD) and quantification (LOQ) of 3 U/L and 1 U/L, respectively
doi: 10.1186/s12967-024-05876-3 47 LiH.HeB.MaN.LiuC.CaiK.ZhangX.et al
Absorption can be reduced by interactions with food, gastrointestinal conditions and dose limits for specific transporters in the gut
Other serious side effects of phentermine-topiramate include suicidal behavior and ideation and serious eye problems possibly leading to permanent vision loss (Vivus 2014)
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