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It has been observed that glutamate production through the appropriate function of GDH pathway has a role in the mitochondrial retrograde signaling that affects changes in nuclear gene expression related to nutrient sensing and TOR signaling [26, 98], aging [99, 100] metabolism [20] and as recently shown, in different types of cancer [101,102,103,104,105,106,107,108]
"Regulation of TIP60 by ATF2 modulates ATM activation"
The study was approved by the Ethics Committee of the University of Granada (Spain) (approval number: 1797-N-17)
Selective transport of GSH across the ER membrane has been shown in mammalian liver microsomes (Banhegyi et al , 1999), and into the sarcoplasmic reticulum of skeletal muscle (Banhegyi et al , 2003)