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Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). New England Journal of Medicine

Oral options: Orlistat : A lipase inhibitor available in prescription strength (Xenical 120 mg) and a lower-dose over-the-counter form (Alli 60 mg)

These popular drugs, used to treat diabetes and obesity, help promote weight loss by reducing appetite and food intake

The residual compound load is higher, and GI sensitivity tends to increase with longer tirzepatide exposure at these doses

The Role of Serotonin in Mood Serotonin acts as a key neurotransmitter, delivering signals associated with well-being, calm, and happiness across the microscopic gaps (synapses) between neurons

You can read more about this in our guide on the Ozempic plateau