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In mice models, B1 cells are shown to produce IgM (natural antibody), which are anti-inflammatory, whereas B2 cells seen in VAT produce IgG that are pathogenic cells associated with obesity-associated inflammation (100)
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It is also non-invasive, which reduces the likelihood of complications typically associated with more aggressive treatments
The FOXO4p53 axis in senescence p53 is a major tumour suppressor and master regulator of cellular stress responses: DNA damage, oxidative stress, oncogene activation
Psychiatry Res 253:2832
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