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Taspoglutide, an experimental diabetes drug built to closely mimic a hormone the body already produces, generated antibodies against itself in about half the patients who took it and systemic allergic reactions in 6%, including anaphylaxis, and Roche stopped dosing patients in the phase 3 trials in 2010
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L., Zhang, L., & Barnes, J
What the animal studies cannot tell us includes optimal human dosing, population-specific responses (elderly, children, pregnancy), long-term safety in humans, rare side effects that require large sample sizes to detect, and interactions with medications or medical conditions
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