Cardiovascular health: Research has shown that Semaglutide and Tirzepatide can reduce the risk of cardiovascular events like heart attack and stroke
A new pilot trial suggests its more than wishful thinking
Int J Oncol 29(3):665672 Kadekaro AL, Andrade LN, Floeter-Winter LM, Rollag MD, Virador V, Vieira W, Castrucci AM (2004) MT-1 melatonin receptor expression increases the antiproliferative effect of melatonin on S-91 murine melanoma cells
In adjusted analyses, semaglutide reduced epigenetic aging across multiple second- and third-generation clocks, including PhenoAge ( 4.9 years/year, p = 0.004), PCGrimAge ( 3.1, p = 0.007), GrimAge V2 ( 2.3, p = 0.009), OMICmAge ( 2.2, p = 0.009), RetroAge ( 2.2, p = 0.030), and DunedinPACE ( 0.09 units, 9% slower, p = 0.01)
10.2174/13816128130111 128 SikiricP.SeparovicJ.AnicT.BuljatG.MikusD.SeiwerthS.et al (1999a)
However, some of these recommendations might not be appropriate for certain patients, including diabetic patients with gastroparesis (slow stomach emptying) who may not be able to increase fiber-rich foods, and patients with significant obesity in whom physical activity is a barrier
