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These strain-dependent effects are primarily mediated through the engagement of specific pathogen-recognition receptors on DCs, including TLR2, TLR9, and nucleotide-binding oligomerization domain-containing protein 2 (NOD2) (165)
Laboratory research has established FOXO4-DRI as an invaluable tool for investigating fundamental questions in aging biology, regenerative medicine, cancer research, and tissue engineering, with its proven efficacy across diverse experimental models enabling researchers to test causal relationships between senescence and age-related phenotypes
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Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes
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