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Safety Data Limits : According to an FDA briefing, animal studies revealed possible liver or bone-related risks at high doses, and current human data are limited
An animal is considered to be in the open area when all four paws are in an open quadrant and in the closed area only when all four paws have crossed from the open to the closed boundary
Am J Respir Crit Care Med 167 : 395399 Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP 2009 Innate immunity against bacterial infection following hyperoxia exposure is impaired in nrf2-deficient mice
The cost-effectiveness of the treatment may be influenced by adherence, which is impacted by treatment goals and tolerability (Witkowski et al., 2018
