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That literature has explored its role across tendon, muscle, gut and vascular models, and its frequently cited in the wider tissue-repair field

Li X, Qian S, He Q, Yang B, Li J, Hu Y

However, evidence remains insufficient

The area under the tongue has a dense network of blood vessels, making it one of the most permeable mucous membranes in the body

Read together with the failed fosgonimeton trial, the takeaway is that the human-relevant evidence base for this class is both thin and, where it touched humans, negative

This can appear as dark spots, post-inflammatory hyperpigmentation, melasma, or a generally dull complexion