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Weight Loss Effects of the GLP-1 Medications The weight-loss effect is due to its direct action on the brains appetite center and on the stomach, which delays gastric emptying

this finding is also aligned with the one reported from Friedrichsen et al

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Trends Biotechnol Liu J, Hasanuzzaman M, Wen H, Zhang J, Peng T, Sun H, Zhao Q (2019) High temperature and drought stress cause abscisic acid and reactive oxygen species accumulation and suppress seed germination growth in rice

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Firstly, GLP-1 and its analogs can cross the BBB (64, 65)