According to FDA prescribing information, gallbladder-related adverse events occurred in clinical trials of semaglutide for weight management (Wegovy) at rates of 2.5% versus 1.0% with placebo, and for tirzepatide (Zepbound) at rates of 2.5% versus 1.0% with placebo
Nature Reviews Molecular Cell Biology, 22 (2), 75-95
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Targeted knockdown of GLP-1 receptors within the LS, but not in the hypothalamus, substantially attenuated liraglutides ability to inhibit feeding and lower body weight
"Wegovy for Weight Loss: Uses, Side Effects, Dosage." STEP 1 trial: 14.9% mean weight loss