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Narcotic medications should be used in combination with one of the non-narcotic drugs
While the weight loss itself often benefits the system, the impact of GLP-1s on reproductive hormones and cycle is a complex area, and it is imperative to use strict contraception and stop treatment immediately if attempting to conceive or upon becoming pregnant due to potential GLP-1 fertility concerns
Studies have demonstrated that the overactivation of microglia into the M1 phenotype induces increased secretion of pro-inflammatory cytokines, and their excessive accumulation in the brain may impair microglial immunologic function and exacerbate AD progression [54]
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