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The pivotal regulatory enzyme pyruvate kinase M2 (PKM2) functions as a central metabolic switch, mechanistically reflecting the Warburg effect observed in hepatocarcinogenesis (65)
This study identified the HNF4A - NCOA4 axis and ferritinophagy as crucial factors in hepatocyte ferroptosis and the pathogenesis of acute liver failure (ALF)
Ferroptosis is involved in both health and cancer, and physiological ferroptosis may contribute to the elimination of deleterious cells to preserve tissue homeostasis and development, whereas pathological ferroptosis may be an important contributor to the development of cancer (38)
Start with a lower concentration (around 10%), patch-test before full use, and introduce products gradually
Carrillo-Garca, C
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