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Studies in cell culture have demonstrated that specific peptide sequences can upregulate procollagen synthesis in dermal fibroblasts, while others influence the activity of matrix metalloproteinases (MMPs) the enzymes responsible for collagen degradation and ECM remodelling
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All inhibitors used were co-administered with Dihexa, that is 1 h pretreatment and co-treatment with a given ototoxin
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Statistical Analysis Sample size calculations were performed at the beginning of this exploratory trial ( n = 40)
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