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Annual monitoring including metabolic panel, HbA1c, lipids, and nutritional markers is recommended

[1] [2] Similarly, the SCALE trials for liraglutide 3mg (Saxenda) documented fatigue as a common adverse reaction

10.1038/s41590-019-0321-5 Nat

Eight biomarkers were found to be independently and directly associated with the baseline number of chronic diseases (that is, cystatin C, hemoglobin A1c (HbA1c), growth differentiation factor 15 (GDF15), leptin, insulin, neurofilament light chain (NfL), creatinine and C-peptide), while hemoglobin was reversely associated with this multimorbidity measure

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To stop PBMs from manipulating the system, legislation must change how PBMs are paid