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GLP-1 drugs show promise for weight management Across the reviewed studies, tirzepatide, semaglutide, and liraglutide consistently led to significant weight loss over one to two years compared with placebo, and the benefits appeared to continue during ongoing treatment

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Life 16 (8), 12201223

Apart from impairing insulin sensitivity and causing water retention, many GHS also lead to increased appetite, weight gain, elevated cortisol, and prolactin.

It was developed at the University of Arizona by Hruby and Hadley and contains two key modifications from native -MSH: a norleucine substitution at position 4 (replacing methionine) and a D-phenylalanine substitution at position 7 (replacing L-phenylalanine)

Diabetes Care 28 , 10921100 (2005)