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Translating animal doses to human equivalents requires consideration of species-specific pharmacokinetic differences

Landmark Papers: Enhanced Recovery Decreases Pulmonary and Cardica Complications After Thoracotomy for Lung Cancer

However, native GLP-1 has a very short half-life of approximately two minutes due to rapid degradation by the enzyme dipeptidyl peptidase-4 (DPP-4)

That can increase the risk of aspiration (food entering the lungs) during anaesthesia

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The once-weekly injection delivered up to 22.6 per cent average weight loss and reduced the incidence of major adverse cardiovascular events