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In terms of molecular mechanisms, ZDHHC3 loss of function resulted in reduced palmitoylation modification of inactive rhodopsin 2 (IRHOM2), which in turn promoted its degradation via the ubiquitin-proteasome pathway and ultimately inhibited the activation of the downstream MAP3K7-JNK signaling pathway (158)

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Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme

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Tal como se representa en la figura 2, el LXR promueve la biosntesis de los AG mientras que el PPAR- induce la oxidacin de stos

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Formichi, C

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