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Clinical pharmacology studies show tirzepatide has a half-life of approximately 5 days, allowing for once-weekly dosing with sustained therapeutic effects (Frias et al., Diabetes Care, 2021)
Recent insights into GLP-1R signaling in beta cells is summarized in (115)
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For example, Sokos et al
Chudasama YV, Gillies CL, Zaccardi F, et al
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