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Stronger, more functional tissue in as little as 14 days in animal models

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First identified in human plasma by Dr

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Replacement with Trp 7 lowers the affinity (IC 50 : 0.26 nM3.3 nM) and strongly lowers the activity (EC 50 : 0.8 nM127 nM)

The disease is characterized by general metabolic derangement, cardiomyopathy, hyperammonemia, hypoglycemia, muscle weakness, and myopathy, in line with the crucial role of carnitine in FAO (Nezu et al., 1999)