These agents are also associated with a minimal risk of hypoglycemia when used as monotherapy or as add-on to metformin monotherapy, but they can contribute to hypoglycemia when used in combination with medications associated with hypoglycemia, such as insulin and insulin secretagogues
The GIP (glucose-dependent insulinotropic polypeptide) receptor component enhances insulin secretion and may contribute to fat metabolism through direct effects on adipose tissue
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