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However, a small percentage of the medicationusually about 5% to 10%is processed through a different pathway involving a specific enzyme

Skin reads this as a kind of internal heat signal, and the sebaceous glands respond by producing more oil to protect the surface

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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects

Two review articles by Graf and colleagues compiled the early body of work (PMID 6145137, PMID 3550726)