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NNMT knockdown in WAT and liver protects against diet-induced obesity by augmenting cellular energy expenditure

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Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake [5] [6]

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However, deficiency is common, especially in people with low stomach acid, digestive conditions, vegan or vegetarian diets, or age-related absorption decline