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In addition, Orai1, a Ca 2+ channel, has emerged as a key regulator of reactive astrocytes by controlling the synthesis and release of a broad range of proinflammatory mediators 113

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Reconstituting the same 5 mg vial with 1 mL instead of 3 mL produces 5,000 mcg/mL, and 100 mcg then occupies 0.02 mL (2 units) rather than 0.06 mL (6 units)

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and iii) doxorubicin itself has long been implicated with futile redox cycling toxicity, specifically within the mitochondria 29