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Dysregulation of autophagy, endolysosomal trafficking, lysosomal function, and mitochondrial integrity not only promotes neuronal dysfunction and death but also contributes to protein aggregation, neuroinflammation, and disease propagation across neural networks
"In the past, if I had lost weight, I got a self-esteem boost, which is almost like dopamine
In animal studies, P21 has been shown to boost levels of BDNF (brain-derived neurotrophic factor), thus promoting neurogenesis (nerve growth) and inhibiting the formation of Amyloid plaques and Tau proteins seen in Alzheimer's disease
Enhanced dopamine transporter (DAT) binding was also observed in the caudate (P = 0.014) and putamen (P = 0.039) (Monti et al., 2016
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