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Both require careful dosing adjustments that should be managed under the guidance of a healthcare provider
Their mechanism of action involves several complementary pathways: Glucose-dependent insulin secretion : They stimulate pancreatic beta cells to release insulin only when blood glucose levels are elevated, reducing the risk of hypoglycaemia compared to some other diabetes medications [1] [3] Glucagon suppression : They inhibit the release of glucagon from pancreatic alpha cells, thereby reducing hepatic glucose production [1] [3] Delayed gastric emptying : They slow the rate at which food leaves the stomach, leading to more gradual glucose absorption and increased satiety Central appetite regulation : They act on receptors in the brain to reduce appetite and food intake These medications are typically administered once weekly or once daily via subcutaneous injection, with the exception of Rybelsus which is taken orally
OZEMs fourth-largest holding, with a 4.41% weighting, Viking Therapeutics NASDAQ: VKTX, currently has its dual GLP-1/GIP agonist, VK2735, in advanced clinical trials for obesity and metabolic disorders
Most common side effects include nausea, diarrhea, bloating, vomiting or constipation
Directions for use: By intramuscular or subcutaneous injection
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