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Therefore, both temporal and spatial considerations of IGF-1R modulation will need to be considered in future trials with these drugs in order to clearly define the benefits and potential risks associated with this treatment, and guide development of strategies that allow for safe and effective long-term human use
Zheng L, Zhu H-Z, Wang B-T, Zhao Q-H, Du X-B, Zheng Y, Jiang L, Ni J-Z, Zhang Y, Liu Q (2016) Sodium selenate regulates the brain ionome in a transgenic mouse model of Alzheimers disease
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